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Methaqualone is a depressant that increases the activity of the GABA receptors in the brain and nervous system. When GABA activity increases, blood pressure drops and the breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia. Methaqualone works well in the bloodstream within several hours, with a half-life of 20–60 hours. Regular users build up a physical tolerance, requiring larger doses for the same effect. Overdose can lead to nervous system shutdown, coma and death. Pregnant women or breastfeeding mothers should not use methaqualone.
Methaqualone was manufactured in the United States under the name Quaalude by the pharmaceutical firms Rorer and Lemmon with the numbers 714 stamped on the tablet, so people often referred to Quaalude as 714s, “Lemmons”, or “Lemmon 714”. Methaqualone was also manufactured in the US under the trade names Sopor and Parest.
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Methaqualone, sold under the brand name Quaalude in the US and Mandrax in the UK and South Africa, is a sedative and hypnotic medication. It is a member of the Quinazolinone class. The sedative hypnotic activity of methaqualone was first noted by researchers in the 1950s. In 1962, methaqualone was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant.
By 1965, it was the most commonly prescribed sedative in Britain, where it has been sold legally under the names Malsed, Malsedin, and Renoval. In 1965, a methaqualone/antihistamine combination was sold as the sedative drug Mandrax, by Roussel Laboratories (now part of Sanofi-Aventis). In 1972, it was the sixth-bestselling sedative in the US, where it was legal under the brand name Quaalude. Quaalude in the United States was originally manufactured in 1965 by the Fort Washington, Pennsylvania, based pharmaceutical firm William H. Quaaludes for sale here cheap and legit with %100 discreet packaging and shipping worldwide.
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